I. Introduction Description of the disease
Your kidneys are a two bean shape organs that are located in the lower back that play a more important role in your overall health than you may realize. You kidneys are filtration system, cleaning waste and extra fluids from your body and producing and balancing chemicals that are necessary for your body to function. Understanding your kidneys and following your kidney diet, by not smoking may help your kidneys better function and longer.
These renal of the kidney cysts are filled with fluid and formed by individual nephrons, the subunits of the kidney. People with PKD may also have cysts in the liver, pancreas and other organs. About 10 to 15 percent may have swellings in the walls of blood vessels in the brain (called aneurysms). In time, virtually all of the nephrons of either kidneys either become cystic or are compressed, distorted and rendered increasingly ineffective by the pressure of adjacent cysts. In the process, both kidneys enlarge to three or four times the normal size, while function decreases.The patient is unaware of the disease unless some complication; hypertension, blood in the urine, pain caused by bleeding into the kidney, a stone or infection, calls attention to the kidney, usually long before kidney failure has developed. Eventually, the kidneys become so large that it is possible to feel them.There are two types of PKD. In the more common type (autosomal dominant PKD) almost half of the affected patients develop chronic kidney failure by the age of 60. A much more unusual type (autosomal recessive PKD) causes kidney failure in early childhood.
Risk factors for the disease
This disease appears to occur all over the world among all socioeconomic and ethnic groups. Men and women are affected equally, and about 500,000 Americans have PKD.
Autosomal dominant PKD is the most common inherited disease in the United States. People get the disease from a parent who has PKD. If...